医学免疫学 英文版 何维 等主编 2008年版

医学免疫学 英文版
作者： 何维 等主编
出版时间： 2008年版
丛编项： 卫生部"十一五"规划教材·全国高等医药教材建设研究会规划教材/全国高等学校教材
内容简介
　　Essential Medical Immunology is written for medical students in the People's Republic of China　and is adapted largely from Immunology （Seventh Edition） by David Male， Jonathan Brostoff， David B　Roth and Ivan Roit， with the permission of Mosby Elsevier Publishers. Information from other sources，including research articles， has also been included. Immunology is an experimental biomedical science concerned with the study of the structure and　function of the immune system in all life-forms， while medical immunology emphasizes on the human　system and the diseases associated with it. Starting from the pioneering observations of people like　Edward Jenner， who in 1798 performed the first vaccination， or Frank Widal who， in 1896， developed　the first serological test， immunology has grown enormously to become an important， complex discipline　that has permeated into many other fields of biology， including such diverse areas as neuroscience and　biotechnology. The book attempts to provide a brief account of immunology to medical students and is divided　broadly into' Basic Immunology and Clinical Immunology'. Although the aim is to keep the text simple　and concise， depth has been given to some areas to provide a more comprehensive understanding for the　more enthusiastic students. We hope students will find the book both informative and user-friendly. We are indebted to Associate Profess~6r Yang Gao， Ms. Xianqian Kong and Ms. Peggy Fung for their　secretarial assistance.
目录
Section I Basic Immunology
　Chapter 1 Overview of the Immune System
INNATE IMMUNITY
Physical and Chemical Barriers
Phagocytic Cells
Auxiliary Cells
Soluble Mediators
Complement Proteins
Toll-like Receptors
ADAPTIVE IMMUNITY
B and T Cells
Cytokines
Specific Immune Responses
Three Phases of Immune Responses
Crosstalk between Innate and Adaptive Immunity
　　IMMUNOPATHOLOGY
　inflammation and Tissue Injury
　 Allergen-induced Immunopathology
　 Autoantigen-induced Immunopathology
　　IMMUNOLOGICAL APPLICATIONS
Vaccination
　　Immunotherapys and immunoassays
　Chapter 2 Cells, Organs and Tissues of the Immune System
IMMUNE CELLS
Innate Immune Cells
Adaptive Immune Cells
IMMUNE CELL SURFACE RECEPTORS FOR ANTIGENS
Pattern-recognition Receptors on Innate Immune Cells
B Cell Receptor on B Cells
T Cell Receptor on T Cells
MHC Molecules
　　IMMUNE ORGANS AND TISSUES
　　Primary Lymphoid Organs-Bone Marrow and Thymus
　　Secondary Lymphoid Organs and Tissues-Spleen, Lymph Nodes
　Chapter 3 Soluble Mediators of the Immune System
ANTIBODIES
Structure of lmmunoglobulins
Bifunctional Activities of lmmunoglobulins
A Vast Repertoire of Antigen-binding Sites
Somatic Hypermutation and Affinity Maturation
COMPLEMENT
Complement Activation Pathways
Complement-mediated Inflammatory Reaction
CYTOKINES
Chapter 4 The Innate Immune Response
COMPONENTS OF INNATE IMMUNITY
Physical and Chemical Barriers
Phagocytic Cells, NK cells, Blood Proteins and Cytokines　and MALT
　　RECOGNITION OF INNATE IMMUNITY
　Pattern Recognition Receptors and Pathogen-associated Molecular Patterns ..
　 NK Cells Recognition via Their Inhibitory Receptors and Activating Receptors
　　RESPONSE MODELS OF INNATE IMMUNITY
Cytotoxicity to Target Cells
Killing Microbes and Inflammation
　Chapter 5 The Adaptive Immune Response
ANTIGEN PRESENTATION
Types of APCs
Antigen Processing
Exogenous Peptides Presented by MHC Class II and Endogenous Peptides Presented by MHC Class
Co-stimulatory Molecules for T Cell Activation
Immunological Synapse
Antigen Presentation and the Course of an Immune Response
　ACTIVATION OF T AND B LYMPHOCYTES
　B Ceils Responses to TI or TD Antigens
　Signal Transduction in T and B Cell Activations
　The Interaction between B Cells and TH Cells :
　Proliferations and Differentiations of Activated T and B Cells
……